Novel Markers for Prostate Cancer To develop a novel serum marker for prostate cancer, and to analyze the efficacy of this marker for detecting prostate cancer.
Coactivators in Androgen-Refractory Prostate Cancer To test the hypothesis that IL-6-induced transactivation of AR is mediated by recruitment of transcriptional coregulator molecules.
A Novel Molecular Target for Prostate Cancer Gene Therapy To study the role of the androgen receptor in the development and progression of prostate cancer.
Androgenic Inactivation of FKHR in Prostate Cancer To determine the mechanisms by which androgens inhibit apoptosis in prostate cancer cells. To determine the proteolytic cleavage site in the FKHR protein. To identify androgen-regulated protease(s) that cleaves FKHR protein.
Dutasteride and Prostate Cancer To determine the effects of the 5 alpha-reductase inhibitor Dutasteride (GlaxoSmithKline) on prostate cancer cells. Microarray chip analysis is being performed to identify genes and pathways affected by treatment with dutasteride with expression levels of candidate genes confirmed using real time PCR. We have posted the initial set of Dutasteride microarray data on this website as a PDF file titled Dutasteride Treatment of LNCaP.