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Evanthia Galanis, M.D.
![]() Evanthia Galanis, M.D.
Location:
Minnesota
SummaryLong-Term Research Aim: To successfully treat solid tumors employing gene transfer and virotherapy approaches. Mid-Term Research Aims: 1. To test oncolytic measles virus derivatives in preclinical tumor models with special focus on gliomas, breast cancer and prostate cancer. 2. To retarget measle virus strains against tumor-specific antigens. 3. To test novel viral delivery approaches such as cell mediated delivery in preclinical models. 4. To test immunomodulatory strategies as a means of further increasing viral replication in vivo 5. To continue with the current and new phase I/phase II gene therapy and virotherapy clinical trials in solid tumors in order to translate promising transgene/vector systems and oncolytic viruses to the clinic. Clinical Trials: I am principal investigator in several clinical trials through the Division of Medical Oncology, examining the therapeutic potential of: 1) a measles virus derivative encoding the human carcinoembryonic antigen (MV-CEA) in patients with recurrent glioblastoma multiforme; 2) a measles virus derivative encoding the sodium iodine symporter gene (MV-NIS) in patients with recurrent ovarian cancer; 3) a phase II trial of Reovirus in patients with metastatic melanoma; 4) a phase II trial of vaccinia virus in patients with hepatocellular carcinoma; 5) several trials of small molecule cell cycle inhibitors such as histone deacetylase inhibitors, proteasome inhibitors, sarc-kinase inhibitors and antiangiogenesis approaches in glioma patients, conducted through the North Central Cancer Treatment Group (NCCTG). Recent publicationsSee a listing of my publications Education
Fellowship
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Hematology/Oncology
Residency
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Internal Medicine
D.Sc
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"Development and application of quantitative immunoenzymatic assays (ELISAS) and immunoblotting techniques in the study of specificity and title of M1- antimitochondrial antibodies (M2-AMA).
M.D.
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