Researcher Profile: Ikeda, Yasuhiro , Ph.D.

Yasuhiro Ikeda, Ph.D.

Location: Minnesota

Primary Appointment
Molecular Medicine
Academic Rank
Assistant Professor of Biochem/Molecular Biology

Summary

Our expertise is using HIV-1-based vectors for gene delivery. We are currently interested in innate/intrinsic antiviral factors, especially those working against HIV-1 and oncolytic viruses. We hope that better understanding of potent natural antiviral factors, such as TRIM5alpha and APOBEC3G, will give us a clue to develop a novel therapeutic approach for HIV-1 infection. Moreover, by avoiding viral restriction factors, we can improve the infectivity of current HIV-1-based vectors. Our projects include characterization of anti-HIV-1 cellular factors for a novel anti-AIDS therapy, establishment of HIV-based vectors yielding higher titers with increased safety, and understanding the molecular mechanisms of oncolytic properties of vesicular stomatitis virus in cancer cells.

Recent publications

See a listing of my publications

Education

Post Doctoral Fellowship – Gene Therapy, Virology. Research: Genetically modified dendritic cells for tumor immunotherapy
University College London, United Kingdom

Post Doctoral Fellowship – Gene Therapy, Virology. Research: Host ranges of lentiviral vectors
University College London, United Kingdom

Ph.D. – Molecular Virology. Thesis title: Biological characterization of feline lymphotropic viruses
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan

DVM – Molecular Virology. BVSc Project: Post-entry block of FIV infection in human cells
Department of Veterinary Microbiology, University of Tokyo, Japan

Areas of Research
HIV-1 vector

Academic Affiliations
Virology and Gene Therapy Program

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