Metabolic Basis for Type 2 Diabetes and Aging Research - K.S. Nair

In Vivo Regulation of Protein Turnover by Hormones

Research in this area addresses whether insulin resistance or insulin deficiency causes mitochondrial dysfunction in diabetes or whether mitochondrial dysfunction causes insulin resistance. We approach these questions by performing human studies involving multiple interventions and measurements of DNA damage, gene expression, fractional synthesis rates of specific proteins (translational rate) and functional measurements including muscle mitochondrial ATP production and endurance capacity.