Advanced Liver Diseases - Patrick S. Kamath

Chronic Liver Disease Studies

Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis

Principal Investigator
Jayant A. Talwalkar, M.D.
Email: talwalkar.jayant@mayo.edu
Secretary phone: 507-284-4823

Study Coordinator
Janice Zimmerman
Phone: 507-266-1287

Specific Aims

Primary:

• To prospectively identify and compare the diagnostic accuracies of quantitative elasticity imaging with serum marker panels for detecting hepatic fibrosis measured by liver biopsy in human subjects
• To prospectively determine the clinical effectiveness of quantitative elasticity imaging techniques with serum marker panels for detecting hepatic fibrosis in human subjects

Study Design

Prospective comparative effectiveness study of serum fibrosis markers, ultrasound-based transient elastography, and magnetic resonance elastography (MRE) versus liver biopsy for the detection of hepatic fibrosis inpatients with nonalcoholic fatty liver disease and chronic hepatitis C. In addition to diagnostic accuracy, several parameters assessing clinical effectiveness, including resource utilization and patient preferences for all testing modalities, will be measured.