Gene and Cell Therapy for Diabetes and Hypertensive Heart Disease - Yasuhiro Ikeda

Antiviral Activities of TRIM Family Proteins

Dr. Ikeda's lab has previously reported that an innate antiviral factor, tripartite motif 5 alpha (TRIM5alpha), can block HIV production.^1,2,3,4 The lab is currently studying the mechanism of TRIM5alpha-mediated antiretroviral activities, as well as possible roles of other TRIM family proteins in innate antiviral activities.

References

1. Sakuma R, et al. Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins. Nature Medicine. 2007;13:631.
2. Sakuma R, et al. Interferon alpha enhances the TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells. Journal of Virology. 2007;81:10201.
3. Sakuma R, et al. Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication. Journal of Biological Chemistry. 2010;285:3784.
4. Ohmine S, et al. Cytoplasmic body component TRIM5alpha requires lipid-enriched microdomains for efficient HIV-1 restriction. Journal of Biological Chemistry. 2010;285:34508.