OVERVIEW

Infectious disease research has the potential for broad application because everyone, in every area of the world, is infected by microbes at some point in their life.

Microbes are simple organisms capable of rapid genetic mutation. Many evolve into new strains that resist available therapies. The ease of international travel and an increasing world population facilitate problems associated with rapid microbial evolution.

Mayo clinicians treat many patients with challenging infections. Our investigators and clinicians collaborate to conduct clinical trials that provide patients with access to novel, experimental diagnostics and therapies for life-threatening infections. Our investigations include emerging pathogens, novel diagnostic and therapeutic approaches, gene therapy, antimicrobial resistance, and counter-bioterrorism, such as a recent test for anthrax.

RESEARCH GOALS

Translational research is the hallmark of Infectious Disease research at Mayo Clinic. Mayo's primary focus is to meet the needs of patients. Therefore, it is the clinical presentation that often drives our research. It is not unusual for basic research discoveries to be immediately translated into a change in clinical approach. We closely integrate our research activities with both education and clinical practice.

Our investigators conduct in vitro and in vivo studies of new antimicrobics, study novel patterns and mechanisms of antimicrobial resistance, track emerging pathogens, and develop unique antimicrobial therapies. Our methods include culture, molecular techniques, and animal models.