Grants

Robert M. Jacobson, M.D.

N01-AI-40065-01
Poland (PI)
09/30/2004-09/29/2009
NIAID
Population Genetics Analysis Program: Immunity to Vaccines/Infections

The overall aim of this project is to estimate the associations between polymorphisms of candidate genes likely to regulate immune response variations, and humoral and cell-mediated immune responses following smallpox vaccination in human subjects.
Role: Co-Investigator

FED200-2000-10062
Poland (PI)
09/29/2000-09/28/2007
CDC
Anthrax Vaccine Adsorbed (AVA): A Human Reactogenicity and Immunogenicity Trial to Address Changes in Route of Administration and Dose Reduction

To conduct a clinical trial of the currently licensed anthrax vaccine among persons 18-62 years, with the purpose of determining immunogenicity and reactogenicity of varying dose schedules changing route of administration.
Role: Co-Investigator

R01 AI48793-07
Poland (PI)
02/01/2001-01/31/2011
NIAID
Immunogenetic Mechanisms of Vaccine Response

The major goals of this project are (1) to estimate the association between specific alleles of HLA class I alleles (A, B, and C), and immune responses following rubella immunization in human subjects, (2) to estimate the association between specific alleles of HLA class II alleles (DRB, DQA, DQB, DPA, and DPB), and immune responses following rubella immunization, (3) to estimate the effects of genetic variation (homozygosity and multigenic interactions) across the class I and/or class II HLA alleles and immune responses following rubella immunization, and (4) to determine the specificity of vaccine-induced immune response associations (antibody and lymphoproliferative responses) following immunization with rubella vaccine compared to models of other live viral vaccines (measles and mumps).
Role: Co-Investigator

R01 AI033144-13
Poland (PI)
06/01/1997-05/31/2008
NIAID
The Immunogenetics of Measles Immunity

The major goals of this project are (1) to estimate associations between specific HLA class I alleles (A, B, and C) and cellular immune responses following measles vaccine; (2) to estimate associations between specific HLA class II alleles (DRB, DQA, DQB, DPA, and DPB) and cellular immune responses following measles vaccine; (3) to estimate the effects of genetic variation (homozygosity and multigenic effects) across the class I and II HLA alleles and cellular immune responses following vaccine; and (4) to estimate associations between cellular and humoral immune responses to measles vaccine within individuals, and to explore the effect of genetic factors on these associations.
Role: Co-Investigator

Walter J. Cook

Evaluation of a Transcutaneous Bilirubin Measurement System For Use in Preventing Severe Bilirubin Toxicity in Full-Term Newborns

CI-10
Comparing transcutaneous bilirubin measurements with serum levels of bilirubin in jaundice newborns.

Young J. Juhn, M.D.

Federal

R21 HD 51902
Individual Housing Data and Socioeconomic Status.
04/2006 - 04/2008
Funded by National Institute of Child Health and Human Development.
The goal is to develop and implement housing based socioeconomic index to overcome the absence of socioeconomic index in commonly using dataset.

R01 AI56133
Asthma and Invasive Pneumococcal Disease
(Juhn)
07/01/05 – 6/30/07
Funded by NIAID.
The goal is to study the invasive pneumococcal disease and its relationship to the incidence and severity of asthma.

R21 AI076567-01
Asthma and IgA Deficiency: A Population-Based Study
12/2007-11/2009
Pending grant submitted to NIAID
The goal is to determine the relationship between asthma and IgA deficiency.

Privately Funded

The Role of Individual Housing Data-Based Socioeconomic Index in Epidemiologic Research
3/1/07 – 2/28/08
Funded by T. Denny Sanford Foundation
The goal is to implement the developed housing based socioeconomic index in epidemiologic research.

Immunogenetic Mechanisms for Increased Susceptibility to Pertussis in People with Asthma
12/2007-11/2010
Pending grant submitted to Sandler’s Foundation
The goal is to identify the underlying mechanisms for increased susceptibility to pertussis in asthma.

Mayo Clinic

Assessment of Susceptibility of Asthmatics to Pertussis.
05/2006 - 02/2008
Funded by Department of Pediatric and Adolescent Medicine, Mayo Clinic.

The Role of HLA DRB1*03 in Airway Inflammation.
06/2006 - 05/2007
Funded by Small Grants Program, Mayo Foundation.

Assessment of the Association of Asthma with Rubella Vaccine Response and HLA Type
06/2006- 05/2008
Pending grant

Asthma and Viral Infections
04/2006-03/2009
Pending grant

The role of asthma status in susceptibility to pneumococcal or pertussis infections
06/2007-05/2009
Pending grant

Completed Grants
Mayo Clinic

Assessment of Socioeconomic Differentials on the Incidence of Asthma in the 1976-1982 Olmsted County Birth Cohort.
02/2000 - 06/2005
Funded by Mayo Clinic Clinician Scholarly Award.
Summary: We found that individual socioeconomic status was associated with asthma incidence and the neighborhood environment played also important role in development of asthma.

Assessment of association between measles vaccine response and childhood asthma.
07/2002 - 06/2005
Funded by Mayo CR20 Funding.
Summary: HLA class II genes play an important role in development of childhood asthma and asthma status resulted in minimal or no influence on measles vaccine response.

Housing Characteristics as Socioeconomic Status Indicator.
11/2002 - 06/2005
Funded by Mayo Clinic Clinician Scholarly Award.
Summary: We found that housing-based socioeconomic status can be formulated and used for assessing socioeconomic status in epidemiologic research.

Factors Associated Parents Care Seeking Behavior.
11/2002 - 06/2005
Funded by Mayo Clinic Clinician Scholarly Award.
Summary: We found.

The Influence of Age and Weight of Refugee Children Upon Arrival in the United States on Subsequent Development of Overweight.
01/2004 - 12/2005
Funded by Mayo Clinic Clinician Scholarly Award.
Summary: Refugee children with underweight at arrival in the US were faster to gain weight than those with normal weight and those with overweight at arrival were more likely to be obese compared to those with normal weight at arrival.

Does the Broselow Tape Accurately Determine Body Weight in the Recent Setting of Increasing Pediatric Obesity Trends?
05/2005 - 04/2006
Funded by Mayo Clinic Clinician Scholarly Award.
Summary: Because of obesity epidemics, Broselow tape approach in calculating medication underestimated dose for a child with overweight.

Other

Characterization of Responses of Day Care Centers to Children Who Are Chronic Carriers of Hepatitis B Virus and Apply to Day Care Centers.
04/1997 - 09/1998
Funded by Yale University.
Summary: Child care directors were limited in knowledge of asthma and they were unwilling to admit children with chronic infections into their day care centers.