DISEASE-BASED RESEARCH FOCUS

BMB faculty are focused on understanding the basic mechanisms of disease research in these areas:

Cancer

• Cell cycle check point-mitotic fidelity
• Growth factors and transcriptional activation
• Metastasis, cell invasion
• Programmed cell death
• Protein degradation and receptor recycling
• Structural function of DNA repair enzymes

Heart/Blood/Lung Diseases

• Defects in cardiac myosins
• Endothelial cell function, angiogenesis
• The structural basis of amyloid aggregation in blood/heart
• Growth factor receptors in pulmonary fibrosis
• Genetics of cardiac development

Central-Peripheral Nervous System Diseases

• Molecular basis of learning and memory
• Neurodegenerative diseases (Huntington's, Friedreich's ataxia, Alzheimer's disease)
• Lipid storage diseases (Niemann Pick Type C; Mucolipidosis Type IV)

Bone Biology and Osteoporosis